Kratek opis projekta
Infrastrukturni center deluje v okviru MIRC UL in ga delno financira tudi Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije.
Infrastrukturni program IC BSL-3+ predstavlja visoko-tehnološko rešitev za razvojno in raziskovalno dejavnost na področju dela z najnevarnejšimi mikroorganizmi, ki jih uvrščamo v 3. in 4. stopnjo biološke varnosti. IC BSL-3+ predstavlja prvi tovrstni center v Sloveniji. Ekipo IC BLS-3+ sestavljajo visoko usposobljeni raziskovalci, ki imajo večletne izkušnje za delo v pogojih laboratorija 3. stopnje biološke varnosti, pod vodstvom doc. zn. sod. dr. Miše Korva, vodje Laboratorija za diagnostiko zoonoz in laboratorija WHO in vodje Laboratorija za diagnostiko Covid-19 na IMI-MF. IC BSL-3+ razpolaga z napredno raziskovalno opremo, ki dovoljuje raziskave mehanizmov odpornosti, interakcije z gostiteljevim imunskim sistemom, razvoj novih diagnostičnih metod, epidemiologije, novih terapevtskih in preventivnih ukrepov ter dejavnike, ki vplivajo na širjenje nalezljivih bolezni. Laboratorij je opremljen s podtlakom, ki zagotavlja nadzorovan pretok zraka skozi sistem HEPA filtrov. Prostori in oprema v laboratoriju so računalniško nadzorovani. Notranjost laboratorija sestavljata dve enoti: prva je opremljena za izolacijo patogenih mikroorganizmov na celični linijah ali kultivacijo na umetnih gojiščih ter biološkima komorama II. in III. stopnje biološke varnosti. Druga enota je namenjena študiji imunopatogeneze, in interakcij med gostiteljem in patogenimi mikroorganizmi. IC BSL-3+ predstavlja raziskovalno stičišče več raziskovalnih programov Univerze v Ljubljani kot tudi drugih javnih raziskovalnih organizacij in gospodarstva ter vključuje tudi posredovanje znaj in izkušenj širši javnosti. Poleg sodelovanja z različnimi raziskovalnimi organizacijami v Sloveniji, IC BSL-3+ nudi podporo tudi državnim inštitucijam pri pripravljanju akcijskih planov in aktivnosti za varovanje splošnega zdravja ljudi ter preprečitev izrednih dogodkov ter uspešno sodeluje v več mednarodnih mrežah in raziskovalnih projektih. Naštete dejavnosti infrastrukturnega programa in povezovanje med različnimi institucijami bodo neposredno prispevale k večji popularizaciji znanosti ter večjemu ugledu slovenske znanosti doma in v tujini.
____________
IC BSL-3+ infrastructure programme represents an integrative, high-tech solution for research and development activities of high risk pathogens classified as biosafety levels 3 and 4 agents. The proposed infrastructure programme is the first of its kind in Slovenia. The IC BSL-3+ team is comprised of highly educated and skilled professionals with long term expertise in the field of highly pathogenic biological agents under the supervision and leadership of Miša Korva, PhD, head of the Laboratory for diagnostics of zoonoses and WHO laboratory and Laboratory for diagnostics of Covid-19 at the Institute of Microbiology and Immunology, Faculty of Medicine. The infrastructure centre enables a multidisciplinary research of microbial pathogenesis, antimicrobial resistance, host-pathogen interactions, development of novel diagnostic methods, epidemiology as well as development and testing of novel therapeutic and preventive measures. The laboratory is equipped with a sustained negative pressure system, which provides a controlled air flow through a system of HEPA filters. Premises and equipment in the laboratory are all computer controlled and restricted. Inside, the laboratory consists of two units: first is equipped for the isolation of pathogenic microorganisms in the cell lines or cultivation on artificial culture media using Class II and III Biological Safety cabinet. The second unit is intended for immune-pathogenesis studies and interactions between a host and pathogenic organisms. The IC BSL-3+ supports collaborative research among different research organizations both in the public sector as well as in the industry. The IC BSL-3+ enables a nation-wide and international dissemination of knowledge and exchange of ideas from different areas of life sciences. The collaborative nature of the centre as well as its scientific excellence and integrity supports popularization of science and greatly increases the recognition of Slovenian scientists in international collaborative research.
The IC BSL3+ is partially funded also by the Slovenian Research and Innovation Agency.